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KMID : 1155520070020010026
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Anesthesia and Pain Medicine
2007 Volume.2 No. 1 p.26 ~ p.29
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The Effect of Dilution with 0.9% Normal Saline on Reducing Withdrawal Movement Induced by Rocuronium Injection
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Kim Yong-Shin
Lee Jung-Ah
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Abstract
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Background: The intravenous injection of rocuronium after loss of consciousness during induction of general anesthesia can cause a withdrawal movement of hand, arm or more than one extremity.We designed this study to examine diluted rocuronium (2 mg/ml) with 0.9% normal saline can reduce withdrawal movement.
Methods: Eighty healthy female patients (aged 19?63) scheduled for general anesthesia were randomly assigned to one of two groups; Group 1 (rocuronium 10 mg/ml) and Group 2 (rocuronium diluted to 2 mg/ml with 0.9% normal saline).After loss of consciousness and eyelid reflex by intravenous injection of thiopental sodium 5 mg/kg, rocuronium (0.6 mg/kg) was injected at the speed of 1 ml/sec in both groups.The incidence and severity of withdrawal movements were assessed by using four-point scales.
Results: The incidence and severity of withdrawal movement in response to rocuronium injection were significantly reduced in Group 2 compared to Group 1 (P ＜ 0.05).
Conclusions: Dilution of rocuronium 10 mg/ml to 2 mg/ml with 0.9% normal saline was significantly effective for reducing withdrawal movement during induction of general anesthesia.This is a simple and effective strategy for preventing rocuronium-induced withdrawal movement. (Anesth Pain Med 2007; 2: 26∼29)
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KEYWORD
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0.9% normal saline, pain, rocuronium, withdrawal movement.
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